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Oxford, England The city of Oxford rivals London when it comes to the title of “most known city” in the UK. This is because of its magnificent history and the presence of Oxford University, one of the most renowned universities in the entire world. Amazing medieval architecture blends well with the modern aspect of the city where you can eat, drink, shop, explore and have a great time.
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This is an exciting role for an enthusiastic scientist interested in antibody expression and cell line development to assist this expanding company. Working within the Antibody Therapeutics division, you will be involved in cell line development for stable cell lines overexpressing therapeutic antibodies. The role is suitable for a candidate with experience in mammalian tissue culture techniques, flow-cytometry, single-cell cloning, expression characterisation, and molecular biology. The successful candidate will acquire a broad range of skills and expertise in various techniques using cutting edge instrumentation and is guaranteed a fulfilling and challenging learning and working experience with this innovative host
Mammalian cell culture for both adherent and suspension cell lines
Recombinant antibody expression in mammalian expression systems
Expression characterisation by flow cytometry, HPLC, and ELISA.
Generation of stable, clonal mammalian cell lines using limiting dilution and cell sorting instrumentation e.g. FACS
Screening platform development for identification and characterisation of engineered cell lines
Working towards a degree in biochemistry, molecular cell biology or related life sciences
Some direct laboratory experience relevant to biological R&D, either academic or industrial
Highly developed interpersonal, written and verbal skills
Very strong focus on generating high-quality data and with meticulous record keeping/data recording
Able to routinely follow written and verbal instructions, often in the form of Standard Operating Procedures ( S.O.P.s)
Individuals should be enthusiastic and be able to contribute actively to the team setting
Diligence and an analytical mindset are essential for methodical working and recording and analysis of data
Team player who understands the importance of their role within the group and strives to work harmoniously with other members of the team.
The Host Company
The host company, a leader in synthetic biology, is a specialist contract research organisation offering services to support the discovery, development and production of biologics and cell and gene therapies. A unifying theme across the portfolio is expertise in designing DNA, optimising expression of proteins, cell line development and improving viral delivery systems. The company is located within purpose-fitted laboratories.