The candidate will work within the Development Neurobiology (GNDe) group led by Dr. Fernando de Castro Soubriet at the Cajal Institute in Madrid.
At the cellular level, our group focuses mainly on the study of oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes; without neglecting the relationship of these cell types with the rest of the glial types and neurons of the central nervous system (CNS). In relation to the above, myelination and remyelination in degenerative processes, as well as the molecular mechanisms underlying these processes, are also the objectives of our studies. Our laboratory is also interested in the study of a protein, anosmin-1. Thus, we are interested in the role of this protein in the development and function of different structures or its possible intervention in degeneration and / or regeneration processes.
We offer the candidate the possibility of learning various techniques of histology, physiology and molecular biology in relation to the elements described in the previous section and we propose a small line of research related to the anosmin-1 protein. This work would be supervised by doctors Fernando de Castro Soubriet and Miguel Marchena and would focus on glial populations in a murine model that overexpresses anosmin-1. This work will include, among other techniques, obtaining samples, staining and light and confocal microscopy. The final part of this work will focus on the compilation of the results obtained and their evaluation by the candidate.
Our intention is that the candidate not only learn various techniques but can collect all his work in the form of a scientific article, communication to congress or similar.