The internship is equivalent to a master-level laboratory project. The undergoing master candidate or a recently graduated master who takes part in this project is planned to acquire experience on the development of a point-of-care assay for follow-up of chronic disease via test of saliva samples. The case of study is Chronic Obstructive Pulmonary Disease (COPD), and the goal of the bio-assay to measure biomarker levels indicating early alarm of worsening episodes. The project is financed the Oslofjordfondet foundation in Norway, which has universities and municipalities as parterns.
The candidate with clinical chemistry/analytical chemistry/biochemistry background can participate in two of the activities:
- Investigation of the relevant pathophysiological factors of COPD with analysis of clinical data collected from COPD patients.
- Conduct ELISA experiments on saliva samples donated from COPD patients. Samples are collected from municipal clinics and partner hospitals.
- Development of a fluorescence bioassay with functionalized graphene quantum dots onto paper for detection of salivary protein biomarkers (C-reactive protein, Interleukin-8 and Matrix Metalloproteinase 9).