The Research Unit on Bioactive Molecules (RUBAM) offers internships for graduate Students in Chemistry, Biology, Biomedicine, and related matters. We offer two different lines of research, depending on the candidate formation.
1) Synthesis, purification and characterization of chemical degraders (PROTACs, AUTACs, LYTACS, etc.). These molecules will be used within the frame of our current research projects on drug discovery in the fields of cancer, viral infection and neurodegeneration. The student will become familiar with the daily work in an organic synthesis laboratory, as well as in the use of the required purification and analytical techniques (MPLC, UPLC, NMR, etc.) for the proper characterization of the synthesized compounds.
2) Biological activity of our “in house” developed chemical degraders. The student will acquire experimental skills in the common general tasks of a cell culture laboratory under the training and the supervision of specialized staff. In addition, the candidate will participate in the characterization of protein complexes with chemical degraders, their activity at decreasing cellular protein contents and the analysis of their phenotypic effects at the cellular level. Cell models will be selected as a function of the target disease.