Interactions among living organisms acquire their outmost sophistication in host-pathogen relationships. Bacteria have a panoply of attack and defense mechanisms, including a number of secretion systems to inject specific proteins and DNA molecules into other cells. As an outcome of secretion, bacteria may share their genetic content with other bacteria, kill competing bacteria, or subvert the metabolism of the infected eukaryotic cell.
Burkholderia cenocepacia, an opportunistic pathogen frequent in the lungs of cystic fibrosis patients, encodes a number of secretion systems, and the biological role they play is controversial. The scientific goal of this research internship is to decipher these roles.
The goal of the internship is to introduce a motivated master student into a research project of her/his own. The student will be integrated into our research team, and will receive training in molecular biology, microbiology, and cellular biology techniques, as well as in the manipulation of human pathogens of biosecurity level 2. After a few months of training, the student is expected to start leading her/his own research, dig in for scientific information, design experiments, analyze/discuss results, and present publicly the results.